Total reviews 422
Total reviews 422
Tests Included: 2
Est. 6-10 (business days) Turnaround
Specimen type: Blood
Quest Diagnostics Location
Methylmalonic acid (MMA) is a substance produced in very small amounts and is necessary for human metabolism and energy production. Homocysteine is an amino acid used by the body to make proteins.Vitamin B12 helps to break down methylmalonic acid and homocysteine. When vitamin B12 is low, blood levels of these two substances rise. The Methylmalonic Acid (MMA) Test is frequently used to help identify and monitor an early or mild vitamin B12 deficiency. Similarly, folate helps to break down homocysteine. When folate is low, blood levels of homocysteine can also rise.Together, these two tests can...
Tests Included: 2
Est. 6-10 (business days) Turnaround
Specimen type: Blood
Quest Diagnostics Location
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Methylmalonic acid (MMA) is a substance produced in very small amounts and is necessary for human metabolism and energy production. Homocysteine is an amino acid used by the body to make proteins.Vitamin B12 helps to break down methylmalonic acid and homocysteine. When vitamin B12 is low, blood levels of these two substances rise. The Methylmalonic Acid (MMA) Test is frequently used to help identify and monitor an early or mild vitamin B12 deficiency. Similarly, folate helps to break down homocysteine. When folate is low, blood levels of homocysteine can also rise.Together, these two tests can provide helpful information about vitamin B12 and folate status. In addition,, these tests may be useful in evaluating macrocytosis, a term used to describe red blood cells that are larger than normal.
Please do not exercise prior to testing. It is best that your blood is taken in a rested state.
Note: Turn around times on results are an estimate and are not guaranteed. The lab may need additional time due to holidays, confirmation/repeat testing, etc. You can contact us to discuss when your results should be ready and we will contact the lab on your behalf immediately.
| Methylmalonic Acid | 87-318 nmol/L |
| Homocysteine | |
| Male | <11.4 umol/L |
| Female | <10.4 umol/L |
Homocysteine is increased by functional deficiency of folate or vitamin B12. Testing for methylmalonic acid differentiates between these deficiencies. Other causes of increased homocysteine include renal failure, folate antagonists such as methotrexate and phenytoin, and exposure to nitrous oxide. Selhub J, et al., Ann Intern Med. 1999;131(5):331-9.
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